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(2) Although the sympathomimetic stimulants, such as amphetamines or methylphenidate, are effective in improving excessive daytime sleepiness in patients with narcolepsy, they have the potential for dependence, have sometimes disabling sympathomimetic side-effects and are associated with tolerance. First-line options include Modafinil/Armodafinil (for excessive daytime sleepiness, EDS), Sodium Oxybate (for EDS and/with cataplexy. No cure of the disease is currently possible.. It is characterized by excessive sleepiness during the day. R-baclofen, a drug used for treating spastic muscles, is more effective at treating narcolepsy than the best drug currently available, research from Stanford Research Institute says. Expert opinion: Concise evaluation of symptoms and type of narcolepsy, coexisting co-morbidities and patients´ distinct needs is mandatory in order to identify a suitable, individual pharmacological treatment. Currently there is no cure for narcolepsy, so treatment focuses on control of symptoms. There is no curative therapy for narcolepsy. Baclofen use in narcolepsy with how to get etodolac over the counter cataplexy therefore warrants further investigation. 8 milligram per kilogram twice nightly — the same dosing regimen given to people with narcolepsy — suppressed cataplexy to a greater extent. Treatment is therefore symptom directed Our findings suggest that baclofen could be helpful for cataplexy at moderate night-time doses, possibly in older non-adolescent patients and could be a safer and cheaper alternative to GHB. Narcolepsy is a chronic neurologic disorder featuring excessive daytime sleepiness. Those with cataplexy have spells of muscle. It isn’t a rare condition, although it is under-recognized and under-diagnosed Cataplexy treatments include antidepressants or a GABA-B agonist, gamma hydroxybutyrate (GHB). GHB is the most effective treatment for cataplexy, but is expensive and can have significant side effects. This rare disease affects 2–5 out of every 10,000 people (1). A 2014 mice study found that giving R-baclofen (R-BAC) 2.

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